sex influence on the formation of alcohol preference and behavior in rats during the long-term caffeine and ethanol intake性影响酒精的偏好和行为的形成在大鼠长期咖啡因和酒精的摄入量.pdf

Journal of Behavioral and Brain Science, 2011, 1, 172-180 doi:10.4236/jbbs.2011.13023 Published Online August 2011 (http://www.SciRP.org/journal/jbbs) Sex Influence on the Formation of Alcohol Preference and Behavior in Rats during the Long-Term Caffeine and Ethanol Intake 1,2 1,2 1 1 1 Eugenia Kutcher , Alexey Egorov , Elena Filatova , Kristina Kulagina , Nadezhda Chernikova 1 Behavior Neurophysiology and Pathology Laboratory, IM Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia 2Department of Psychiatry and Addictions, Medical Faculty , St. Petersburg State University, St. Petersburg, Russia E-mail : draegorov@mail.ru Received March 23, 2011; revised April 11, 2011; accepted May 4, 2011 Abstract Last years the intake of energy drinks (drinks containing caffeine and alcohol) both in young men and women has been increased. However the investigators do not pay attention to the analysis of gender differences. The goal of the study was the investigation of ethanol and caffeine influence on the alcohol preference formation and behavior in male and female rats under the conditions of long-term experiment. It has been found that six month intake of caffeine, ethanol and their combination has led to the increase of alcohol preference both in male and female rats. Alcohol preference was formed earlier in rats consumed combination of caffeine with ethanol, later on in rats consumed ethanol. In animals consumed caffeine the strong alcohol preference did not form up to the end of the experiment. Alcohol p