significance of cd44 and cd24 as cancer stem cell markers an enduring ambiguity意义cd44和cd24癌症干细胞标记一个持久的模棱两可.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 708036, 11 pages doi:10.1155/2012/708036 Review Article Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity Appalaraju Jaggupilli1 and Eyad Elkord1, 2 1 Biomedical Research Centre, School of Environment Life Sciences, University of Salford, Salford M5 4WT, UK 2 Department of Medical Oncology, School of Cancer and Enabling Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester M20 4BX, UK Correspondence should be addressed to Eyad Elkord, e.elkord@salford.ac.uk Received 8 February 2012; Accepted 1 April 2012 Academic Editor: Michael H. Kershaw Copyright © 2012 A. Jaggupilli and E. Elkord. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis, heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a new insight in cancer treatment. However, prospective identification, charac- terization, and isolation of these CSCs have been a major challenge. Many studies were performed on surface markers for potential identification and isolation of CSCs. Lack of universal expression of surface markers limits their usage and no best combination of markers has yet been confirmed to identify CSCs capable of initiating and metastasizing tumours. CD44, a hyaluronic acid receptor, is one of the most commonly studied surface markers, which is expressed by almost every tumour cell. CD24, a heat stable antigen, is another surface marker express