structurally diverse metal coordination compounds, bearing imidodiphosphinate and diphosphinoamine ligands, as potential inhibitors of the platelet activating factor结构多样的金属配位化合物,轴承imidodiphosphinate diphosphinoamine配体,作为潜在的抑制剂的血小板激活因子.pdf

Hindawi Publishing Corporation Bioinorganic Chemistry and Applications Volume 2010, Article ID 731202, 8 pages doi:10.1155/2010/731202 Research Article Structurally Diverse Metal Coordination Compounds, Bearing Imidodiphosphinate and Diphosphinoamine Ligands, as Potential Inhibitors of the Platelet Activating Factor Alexandros B. Tsoupras,1 Maria Roulia,2 Eleftherios Ferentinos,2 Ioannis Stamatopoulos,2 Constantinos A. Demopoulos,1 and Panayotis Kyritsis2 1 Biochemistry Laboratory, Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece 2 Inorganic Chemistry Laboratory, Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece Correspondence should be addressed to Panayotis Kyritsis, kyritsis@chem.uoa.gr Received 15 March 2010; Accepted 3 May 2010 Academic Editor: Spyros Perlepes Copyright © 2010 Alexandros B. Tsoupras et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. − Metal complexes bearing dichalcogenated imidodiphosphinate [R2 P(E)NP(E)R ] ligands (E = O, S, Se, Te), which 2 act as (E,E) chelates, exhibit a remarkable variety of three-dimensional structures. A series of such complexes, namely, square-planar [Cu {(OPPh )(OPPh )N-O, O} ], tetrahedral [Zn{(EPPh )(EPPh )N-