sterol lipid metabolism in down syndrome revisited down syndrome is associated with a selective reduction in serum brassicasterol levels固醇脂质代谢在唐氏综合症贫苦唐氏综合症与选择性降低血清菜子固醇水平.pdf

Hindawi Publishing Corporation Current Gerontology and Geriatrics Research Volume 2012, Article ID 179318, 11 pages doi:10.1155/2012/179318 Research Article Sterol Lipid Metabolism in Down Syndrome Revisited: Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels 1 1 ¨ 2 3 Gavin Tansley, Daniel T. Holmes, Dieter Lutjohann, Elizabeth Head, and Cheryl L. Wellington1 1 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada V5Z 4H4 2 Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, D-53127 Bonn, Germany 3 Department of Molecular and Biomedical Pharmacology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40356, USA Correspondence should be addressed to Cheryl L. Wellington, cheryl@cmmt.ubc.ca Received 22 October 2011; Accepted 22 February 2012 Academic Editor: Wayne Silverman Copyright © 2012 Gavin Tansley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Over the past 15 years, insights into sterol metabolism have improved our understanding of the relationship between lipids and common conditions such as atherosclerosis and Alzheimer’s Disease (AD). A better understanding of sterol lipid metabolism in individuals with Down Syndrome (DS) may help elucidate how this population’s unique metabolic characteristics influence their risks for atherosclerosis and AD. To revisit the question of whether sterol lipid parameters may be altered in DS subjects,