stability analysis and optimal control of a vector-borne disease with nonlinear incidence稳定性分析和与非线性最优控制病媒传播的疾病的发病率.pdf

Hindawi Publishing Corporation Discrete Dynamics in Nature and Society Volume 2012, Article ID 595487, 21 pages doi:10.1155/2012/595487 Research Article Stability Analysis and Optimal Control of a Vector-Borne Disease with Nonlinear Incidence Muhammad Ozair,1 Abid Ali Lashari,1 Il Hyo Jung,2 and Kazeem Oare Okosun3 1 Centre for Advanced Mathematics and Physics, National University of Sciences and Technology, H-12 Campus, Islamabad 44000, Pakistan 2 Department of Mathematics, Pusan National University, Busan 609-735, Republic of Korea 3 Department of Mathematics, Vaal University of Technology, Andries Potgieter Boulevard, Private Bag X021, Vanderbijlpark 1900, South Africa Correspondence should be addressed to Il Hyo Jung, ilhjung@pusan.ac.kr Received 29 July 2012; Revised 17 September 2012; Accepted 17 September 2012 Academic Editor: M. De la Sen Copyright q 2012 Muhammad Ozair et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The paper considers a model for the transmission dynamics of a vector-borne disease with nonlinear incidence rate. It is proved that the global dynamics of the disease are completely determined by the basic reproduction number. In order to assess the effectiveness of disease control measures, the sensitivity analysis of the basic reproductive number R0 and the endemic proportions with respect to epidemiological and demographic parameters are provided. From the results of the sensitivity analysis, the model is modified to assess the impact of three control measures; the p