a human-specific de novo protein-coding gene associated with human brain functions人类新创蛋白质编码基因与人类大脑功能.pdfVIP

A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions 1 2 3 4 4 5 Chuan-Yun Li , Yong Zhang , Zhanbo Wang , Yan Zhang , Chunmei Cao , Ping-Wu Zhang , Shu-Juan 1 1 6 6 4 5 7 1 Lu , Xiao-Mo Li , Quan Yu , Xiaofeng Zheng , Quan Du , George R Uhl , Qing-Rong Liu *, Liping Wei * 1 Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China, 2 Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America, 3 Department of Pathology, Chinese PLA General Hospital, Beijing, China, 4 Institute of Molecular Medicine, Peking University, Beijing, China, 5 Molecular Neurobiology Branch, NIDA, Baltimore, Maryland, United States of America, 6 Department of Biochemistry and Molecular Biology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China, 7 Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, Maryland, United States of America Abstract To understand whether any human-specific new genes may be associated with human brain functions, we computationally screened the genetic vulnerable factors identified through Genome-Wide Association Studies and linkage analyses of nicotine addiction and found one human-specific de novo protein-coding gene, FLJ33706 (alternative gene symbol C20orf203). Cross-species analysis revealed interesting