原创力文档a low-tech analytical method for diethylcarbamazine citrate in medicated salt枸橼酸乙胺嗪在药用盐的低技术含量的分析方法.pdfVIP
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a low-tech analytical method for diethylcarbamazine citrate in medicated salt枸橼酸乙胺嗪在药用盐的低技术含量的分析方法
A Low-Tech Analytical Method for Diethylcarbamazine
Citrate in Medicated Salt
1 1 2 1 1
Abigail Weaver , Patrick Brown , Shannon Huey , Marco Magallon , E. Brennan Bollman , Dominique
3 4 1
Mares , Thomas G. Streit , Marya Lieberman *
1 Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America, 2 Brigham Young University, Provo, Utah, United
States of America, 3 Group SPES, Port-au-Prince, Haiti, 4 Department of Biology, University of Notre Dame, Notre Dame, Indiana, United States of America
Abstract
The World Health Organization has called for an effort to eliminate Lymphatic Filariasis (LF) around the world. In regions
where the disease is endemic, local production and distribution of medicated salt dosed with diethylcarbamazine (DEC) has
been an effective method for eradicating LF. A partner of the Notre Dame Haiti program, Group SPES in Port-au-Prince, Haiti,
produces a medicated salt called Bon Sel. Coarse salt is pre-washed and sprayed with a solution of DEC citrate and
potassium iodate. Iodine levels are routinely monitored on site by a titrimetric method. However, the factory had no
method for monitoring DEC. Critical analytical issues include 1) determining whether the amount of DEC in each lot of Bon
Sel is within safe and therapeutically useful limits, 2) monitoring variability within and between production runs, and 3)
determining the effect of a common local practice (washing salt before use) on the availability of DEC. This paper describes
a novel titrimetric method for analysis of DEC citrate in medicated salt. The analysis needs no electrical power and requires
only a balance, volu
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