原创力文档a malaria vaccine that elicits in humans antibodies able to kill plasmodium falciparum一种疟疾疫苗,抒发人类抗体能够杀死恶性疟原虫.pdfVIP
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a malaria vaccine that elicits in humans antibodies able to kill plasmodium falciparum一种疟疾疫苗,抒发人类抗体能够杀死恶性疟原虫
Open access, freely available online PLoS MEDICINE
A Malaria Vaccine That Elicits in Humans
Antibodies Able to Kill Plasmodium
falciparum
1* 2 1 3 1 1
Pierre Druilhe , Franc¸ois Spertini , Daw Soesoe , Giampietro Corradin , Pedro Mejia , Subhash Singh ,
2 4 1 1
Regine Audran , Ahmed Bouzidi , Claude Oeuvray , Christian Roussilhon
1 Biomedical Parasitology Unit, Pasteur Institute, Paris, France, 2 Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland,
3 Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland, 4 Sedac Therapeutics, Lille, France
Competing Interests: PD, DS, PM, A B S T R A C T
SS, CO, and CR are affiliated with
the Pasteur Institute, which holds a Background
patent on merozoite surface
protein 3.
Plasmodium falciparum merozoite surface protein 3 is a malaria vaccine candidate that was
Author Contributions: PD designed identified, characterised, and developed based on a unique immuno-clinical approach. The
the study. DS, GC, PM, SS, and RA vaccine construct was derived from regions fully conserved among various strains and
performed the biological
experiments. PD, SS, RA, and CR containing B cell epitopes targeted by human antibodies (from malaria-immune adults) that are
analyzed the data. FS organized the able to mediate a monocyte-dependent parasite killing effect. The corresponding long
clinical trial. AB and CO pro
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