原创力文档a commensal helicobacter sp. of the rodent intestinal flora activates tlr2 and nod1 responses in epithelial cells一个共生体幽门螺杆菌sp.啮齿动物的肠道菌群在上皮细胞激活tlr2和nod1响应.pdfVIP
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a commensal helicobacter sp. of the rodent intestinal flora activates tlr2 and nod1 responses in epithelial cells一个共生体幽门螺杆菌sp.啮齿动物的肠道菌群在上皮细胞激活tlr2和nod1响应
A Commensal Helicobacter sp. of the Rodent Intestinal
Flora Activates TLR2 and NOD1 Responses in Epithelial
Cells
1 2 2 3,4
Nadia Chaouche-Drider , Maria Kaparakis , Abdulgader Karrar , Maria-Isabel Fernandez , Letitia A. M.
5,6 ´ ˆ 5 1,7,8 9 5,6
Carneiro , Jerome Viala , Ivo Gomperts Boneca , Anthony P. Moran , Dana J. Philpott , Richard L.
Ferrero1,2*
´ ´ ´
1 Institut Pasteur, Unite de Pathogenie Bacterienne des Muqueuses, Paris, France, 2 Department of Microbiology, Monash University, Clayton, Victoria, Australia, 3 Institut
´ ´ ´ ´ ´
Pasteur, Unite de Pathogenie Microbienne Moleculaire, Paris, France, 4 INSERM U389, Paris, France, 5 Institut Pasteur, Groupe d’Immunite Innee et Signalisation, Paris,
´ ´ ´
France, 6 Department of Immunology, University of Toronto, Toronto, Ontario, Canada, 7 Institut Pasteur, Groupe de Biologie et Genetique de la Paroi Bacterienne, Paris,
France, 8 INSERM, Groupe Avenir, Paris, France, 9 Department of Microbiology, National University of Ireland, Galway, Ireland
Abstract
Helicobacter spp. represent a proportionately small but significant component of the normal intestinal microflora of animal
hosts. Several of these intestinal Helicobacter spp. are known to induce coliti
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