原创力文档a common and unstable copy number variant is associated with differences in glo1 expression and anxiety-like behavior一个常见的和不稳定拷贝数变异与glo1表达和焦虑行为的差异.pdfVIP
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a common and unstable copy number variant is associated with differences in glo1 expression and anxiety-like behavior一个常见的和不稳定拷贝数变异与glo1表达和焦虑行为的差异
A Common and Unstable Copy Number Variant Is
Associated with Differences in Glo1 Expression and
Anxiety-Like Behavior
1 2 3 2 2 2
Richard Williams IV , Jackie E. Lim , Bettina Harr , Claudia Wing , Ryan Walters , Margaret G. Distler ,
3 4 5 4 2 6
Meike Teschke , Chunlei Wu , Tim Wiltshire , Andrew I. Su , Greta Sokoloff , Lisa M. Tarantino , Justin O.
Borevitz7, Abraham A. Palmer2,8*
1 Committee on Computational Neuroscience, University of Chicago, Chicago, Illinois, United States of America, 2 Department of Human Genetics, University of Chicago,
Chicago, Illinois, United States of America, 3 Max-Planck-Institute for Evolutionary Biology, Department of Evolutionary Genetics, Ploen, Germany, 4 Genomics Institute of
the Novartis Research Foundation, San Diego, California, United States of America, 5 Department of Pharmacotherapy and Experimental Therapeutics, School of
Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America, 6 Department of Psychiatry, School of Medicine, University of North Carolina,
Chapel Hill, North Carolina, United States of America, 7 Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America,
8 Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, United States of America
Abstract
Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We
used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby
identified a ,475 kb
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