原创力文档a combined synthetic-fibrin scaffold supports growth and cardiomyogenic commitment of human placental derived stem cells联合synthetic-fibrin支架支持增长和cardiomyogenic人类胎盘干细胞衍生的承诺.pdfVIP
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a combined synthetic-fibrin scaffold supports growth and cardiomyogenic commitment of human placental derived stem cells联合synthetic-fibrin支架支持增长和cardiomyogenic人类胎盘干细胞衍生的承诺
A Combined Synthetic-Fibrin Scaffold Supports Growth
and Cardiomyogenic Commitment of Human Placental
Derived Stem Cells
1 2. 1. 2. 1 3
Antonella Lisi , Enrica Briganti , Mario Ledda , Paola Losi , Settimio Grimaldi , Rodolfo Marchese ,
Giorgio Soldani2*
1 Institute of Translational Pharmacology, National Research Council (C.N.R.), Roma, Italy, 2 Institute of Clinical Physiology, National Research Council (C.N.R.), Massa, Italy,
3 Research Center, S. Peter Hospital FBF, Rome, Italy
Abstract
Aims: A potential therapy for myocardial infarction is to deliver isolated stem cells to the infarcted site. A key issue with this
therapy is to have at one’s disposal a suitable cell delivery system which, besides being able to support cell proliferation and
differentiation, may also provide handling and elastic properties which do not affect cardiac contractile function. In this
study an elastic scaffold, obtained combining a poly(ether)urethane-polydimethylsiloxane (PEtU-PDMS) semi-interpene-
trating polymeric network (s-IPN) with fibrin, was used as a substrate for in vitro studies of human amniotic mesenchymal
stromal cells (hAMSC) growth and differentiation.
Methodology/Principal Findings: After hAMSC seeding on the fibrin side of the scaffold, cell metabolic activity and
proliferation were evaluated by WST-1 and bromodeoxyuridine assays. Morphological changes and mRNAs expression for
cardiac differentiation markers in the hAMSCs were examined using immunofluorescence and RT-PCR analysis. The
beginning of cardiomyogenic commitment of hAMSCs grown on the scaffold was induced, for the first time in this cell
population,
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