原创力文档a mammal-specific doublesex homolog associates with male sex chromatin and is required for male meiosis一个mammal-specific doublesex同族体同事与男性性染色质和需要男性减数分裂.pdfVIP
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a mammal-specific doublesex homolog associates with male sex chromatin and is required for male meiosis一个mammal-specific doublesex同族体同事与男性性染色质和需要男性减数分裂
A Mammal-Specific Doublesex Homolog
Associates with Male Sex Chromatin
and Is Required for Male Meiosis
1,2 3,4,5 6 6 3,4,5
Shinseog Kim , Satoshi H. Namekawa , Lisa M. Niswander , Jeremy O. Ward , Jeannie T. Lee ,
Vivian J. Bardwell1,2, David Zarkower1,2*
1 Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America, 2 Biochemistry, Molecular Biology,
and Biophysics Graduate Program, University of Minnesota, Minneapolis, Minnesota, United States of America, 3 Department of Molecular Biology, Massachusetts General
Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States
of America, 5 Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America, 6 Department of Biology, Middlebury College,
Middlebury, Vermont, United States of America
Gametogenesis is a sexually dimorphic process requiring profound differences in germ cell differentiation between the
sexes. In mammals, the presence of heteromorphic sex chromosomes in males creates additional sex-specific
challenges, including incomplete X and Y pairing during meiotic prophase. This triggers formation of a
heterochromatin domain, the XY body. The XY body disassembles after prophase, but specialized sex chromatin
persists, with further modification, through meiosis. Here, we investigate the function of DMRT7, a mammal-specific
protein related to the invertebrate sexual regulators Doublesex and MAB-3. We find that DMRT7 preferentially
localizes to the XY body in the pachyten
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