原创力文档a novel approach to selectively target neuronal subpopulations reveals genetic pathways that regulate tangential migration in the vertebrate hindbrain一种新颖的方式选择性目标神经元亚种群揭示基因调控机制调节脊椎动物后脑的切向迁移.pdfVIP
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a novel approach to selectively target neuronal subpopulations reveals genetic pathways that regulate tangential migration in the vertebrate hindbrain一种新颖的方式选择性目标神经元亚种群揭示基因调控机制调节脊椎动物后脑的切向迁移
A Novel Approach to Selectively Target Neuronal
Subpopulations Reveals Genetic Pathways That Regulate
Tangential Migration in the Vertebrate Hindbrain
1 1 2,3 1,4
Karsten Benzing , Stefanie Flunkert , Andreas Schedl , Dieter Engelkamp *
1 Max Planck Institute for Brain Research, Department of Neuroanatomy, Frankfurt, Germany, 2 INSERM UMR636, Centre de Biochimie, Nice, France, 3 University of Nice
¨
Sophia Antipolis, Nice, France, 4 Department of Biology, Friedrich-Alexander-University of Erlangen-Nurnberg, Erlangen, Germany
Abstract
Vertebrate genes often play functionally distinct roles in different subsets of cells; however, tools to study the cell-specific
function of gene products are poorly developed. Therefore, we have established a novel mouse model that enables the
visualization and manipulation of defined subpopulations of neurons. To demonstrate the power of our system, we
dissected genetic cascades in which Pax6 is central to control tangentially migrating neurons of the mouse brainstem.
Several Pax6 downstream genes were identified and their function was analyzed by over-expression and knock-down
experiments. One of these, Pou4f2, induces a prolonged midline arrest of growth cones to influence the proportion of
ipsilaterally versus contralaterally settling neurons. These results demonstrate that our approach serves as a versatile tool to
study the function of genes involved in cell migration, axonal pathfinding, and patterning processes. Our model will also
serve as a general tool to specifically over-express any gene in a defined subpopulation of neurons and shou
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