a novel evolution-based method for detecting gene-gene interactions一种新颖的基于进化的系统,该方法检测基因基因的相互作用.pdfVIP

A Novel Evolution-Based Method for Detecting Gene- Gene Interactions 1,2,3 2 3 3 3 4 1 Shaoqi Rao *, Manqiong Yuan , Xiaoyu Zuo , Weiyang Su , Fan Zhang , Ke Huang , Meihua Lin , Yuanlin Ding1 1 Department of Medical Statistics and Epidemiology, School of Public Health, Guangdong Medical College, Dongguan, Guangdong, China, 2 Department of Statistical Sciences, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou, Guangdong, China, 3 Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong, China, 4 Institute of Blood Transfusion, Guangzhou Blood Center, Guangzhou, Guangdong, China Abstract Background: The rapid advance in large-scale SNP-chip technologies offers us great opportunities in elucidating the genetic basis of complex diseases. Methods for large-scale interactions analysis have been under development from several sources. Due to several difficult issues (e.g., sparseness of data in high dimensions and low replication or validation rate), development of fast, powerful and robust methods for detecting various forms of gene-gene interactions continues to be a challenging task. Methodology/Principal Findings: In this article, we have developed an evolution-based method to search for genome-wide epistasis in a case-control design. From an evolutionary perspective, we view that human diseases originate from ancient mutations and consider that the underlying genetic variants play a role in differentiating human population into the healthy and the diseased. Based on this concept, traditional evolutionary measure, fixation index (Fst) for two unlinked loci, which measures the genetic dista