生长因子在正畸牙移动牙周组织改建中作用.docVIP

生长因子在正畸牙移动牙周组织改建中作用[摘要]正畸牙移动是在机械应力作用下多种因子介导的牙周组织改建。随着现代试验技术的发展，研究者们开始在分子和基因水平研究正畸牙移动的生物学特征。在各种参与牙周组织改建的细胞因子中，生长因子是重要的调节因子之一。了解其在正畸牙移动过程中对牙周组织改建的具体作用机制，有助于正畸医师更好地理解正畸牙移动的生物学行为，指导其在正畸临床上的应用。本文就正畸牙移动的生物学基础、正畸牙移动过程中牙周组织的变化、生长因子在牙周组织改建中的作用等研究进展作一综述。 [关键词]生长因子；正畸牙移动；牙周组织改建 [中图分类号]R 783.5[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.02.033 Effects of growth factors on the periodontal tissue remodeling during orthodontic tooth movementPeng Peng, Cai Ping.[The State Key Laboratory Breeding Base of Basic Science of Stomatology（Hubei-MOST） Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China] [Abstract]Orthodontic tooth movement is achieved by the periodontal tissue remodeling in response to mechanical loading and is believed to be mediated by several host mediators. With the development of modern experimental techniques, the researchers have been able to investigate the biological characteristics of orthodontic tooth movement at the molecular and genetic level. The growth factor is one of the most important cytokines which play an important role in the periodontal tissue remodeling. Therefore, a thoroughly awareness of the extensional regulatory mechanism of growth factors is essential to understand the biological behaviour of orthodontic tooth move－ment, and to the application of growth factors in orthodontic clinic. This article reviews the research progress of the biological foundation and the periodontal tissue responses during orthodontic tooth movement and effects of growth factors on the periodontal tissue remodeling. [Key words]growth factor；orthodontic tooth movement；periodontal tissue remodeling 正畸牙移动以牙和牙周组织改建为特征，包括牙髄、牙周膜、牙槽骨和牙龈的改建。牙周组织改建是牙移动的前提，其在组织、细胞、分子和基因水平都有相应的生物学表现[1]。牙周组织改建过程受到各种分子的调节作用，生长因子在这一过程中起着十分重要的作用。本文就正畸牙移动过程中，各种生长因子在牙周组织改建中的作用作一综述。 1正畸牙移动的生物学基础 牙周组织改建是正畸牙移动的生物学基础。当正畸矫治力作用于牙齿后，牙周组织的细胞外基质、细胞膜、细胞骨架、核内蛋白质和基因组的微环境处于机械应激状态，从而诱导包括神经递质和细胞因子以及花生四烯酸代谢产物等在内的各种生物活