血清CA125、CA199联合多普勒超声血流显像对卵巢上皮性肿瘤诊断价值.docVIP

血清CA125、CA199联合多普勒超声血流显像对卵巢上皮性肿瘤诊断价值[摘要] 目的：探讨血清CA125、CA199联合多普勒超声血流显像在早期卵巢上皮性恶性肿瘤诊断中的价值。方法：对2006年1月～2008年12月我院的102例卵巢上皮性肿瘤患者及42例对照组妇女分别进行血清CA125、CA199及多普勒超声检测，并分别以血清CA125＞35 kU/L、CA125＞100 kU/L，CA199＞37 kU/L、CA199＞70 kU/L，阻力指数（RI）＜0.5、RI＜0.6作为阳性结果，比较各种指标对卵巢上皮性恶性肿瘤预测的敏感性、特异性、阳性预测值和阴性预测值。结果：卵巢上皮性恶性肿瘤患者血清CA125、CA199水平明显高于对照组和良性肿瘤组，而良性肿瘤组和对照组间无显著性差异（P＞0.05）。多普勒血流显像：恶性肿瘤组RI显著低于良性肿瘤组。单独应用CA125＞100 kU/L敏感性为78.4%，特异性为88.4%，单独应用CA199＞70 kU/L敏感性为49.0%，特异性为86.0%。多普勒超声（RI＜0.5）联合上述两种血清学指标，敏感性为94.2%，特异性为95.3%。结论：血清CA125、CA199联合多普勒超声血流显像可明显提高卵巢上皮性恶性肿瘤诊断的敏感性和特异性。 [关键词] 卵巢上皮性肿瘤；CA125；CA199；多普勒超声 [中图分类号] R737.31[文献标识码]A [文章编号]1673-7210（2009）05（b）-029-03 The diagnostic value of serum CA125 and CA199 combined with Doppler ultrasound flow imaging in patients with epithelial ovarian tumor SUN Yue (Department of Gynecology and Obstetrics, the General Hospital of Bengang, Benxi 117000, China) [Abstract] Objective: To investigate the diagnostic value of serum CA125 and CA199 combined with Doppler ultrasound flow imaging in the early epithelial ovarian m alignancies. Methods: From January 2006 to December 2008, 102 cases of epithelial ovarian tumor patients and 42 cases of control group women in our hospital were assessed serum CA125, CA199 and Doppler ultrasonic testing. The levels of serum CA12535 kU/L, CA125100 kU/L; CA19937 kU/L, CA19970 kU/L; resistance index (RI) 0.05). As to Doppler flow imaging, RI m alignant group was significantly lower than benign group. Single application CA125100 kU/L, the sensitivity and the specificity were 78.4% and 88.4% respectively. Single application CA19970 kU/L, the sensitivity andspecificity were 49.0% and 86.0% respectively. Doppler ultrasound (RI 1.3 统计学处理 数据以均数±标准差（x±s）表示，采用SPSS 10.0统计软件进行χ2检验和方差分析，P＜0.05表示差异有统计学意义。 2 结果 2.1 病理结果 102例卵巢上皮性肿瘤患者中，45例为良性肿瘤，5例为交界性肿瘤，52例为恶性肿瘤。52例恶性肿瘤中，Ⅰ、Ⅱ期32例，Ⅲ、Ⅳ期20例；浆液性囊腺癌30例，黏液性囊腺癌12例，透明细胞癌、子宫内膜样癌各3例，移行细胞癌、未分化癌各2例。 将卵巢上皮性肿瘤患者分为良性、恶性肿瘤两组，因交界性肿瘤例数较少而未列入比较。 2.2 各组患者血清CA125、C