artemisinin versus nonartemisinin combination therapy for uncomplicated malaria randomized clinical trials from four sites in uganda简单的疟疾的青蒿素与nonartemisinin联合治疗随机临床试验从四个网站在乌干达.pdfVIP

Open access, freely available online PLoS MEDICINE Artemisinin versus Nonartemisinin Combination Therapy for Uncomplicated Malaria: Randomized Clinical Trials from Four Sites in Uganda 1 2 1 2 3 1 Adoke Yeka , Kristin Banek , Nathan Bakyaita , Sarah G. Staedke , Moses R. Kamya , Ambrose Talisuna , 3 3 1 2 4 2 Fred Kironde , Samuel L. Nsobya , Albert Kilian , Madeline Slater , Arthur Reingold , Philip J. Rosenthal , 5 2* Fred Wabwire-Mangen , Grant Dorsey 1 Ministry of Health, Kampala, Uganda, 2 Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America, 3 Makerere University Medical School, Kampala, Uganda, 4 Division of Epidemiology, School of Public Health, University of California, Berkeley, California, United States of America, 5 Institute of Public Health, Makerere University, Kampala, Uganda Competing Interests: The authors A B S T R A C T have declared that no competing interests exist. Background Author Contributions: AY, KB, NB, SGS, MRK, AT, AK, AR, PJR, FWM, and Drug resistance in Plasmodium falciparum poses a major threat to malaria control. GD designed the study. AY, KB, NB, Combination antimalarial therapy including artemisinins has been advocated recently to SGS, MRK, AT, FK, SLN, MS, FWM, and improve efficacy and limit the spread of resistance, but artemisinin