arterial embolization hyperthermia using as2o3 nanoparticles in vx2 carcinoma–induced liver tumors动脉栓塞高热使用as2o3纳米颗粒在vx2 carcinoma-induced肝脏肿瘤.pdfVIP

Arterial Embolization Hyperthermia Using As O 2 3 Nanoparticles in VX2 Carcinoma–Induced Liver Tumors 1 1 2 1 1 1 3 Hui Yu , Guang-Yu Zhu , Rui-Zhi Xu , Huan-Zhang Niu , Qin Lu , Guo-Zhao Li , Zi-Yu Wang , 3 2 1 Dong-Sheng Zhang , Ning Gu , Gao-Jun Teng * 1Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhong-Da Hospital, Medical School of Southeast University, Nanjing, China, 2 Jiangsu Laboratory for Biomaterials and Devices, State Key Laboratory of BioElectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China, 3 Department of Pathology and Pathophysiology, Medical School of Southeast University, Nanjing, China Abstract Background: Combination therapy for arterial embolization hyperthermia (AEH) with arsenic trioxide (As O ) nanoparticles 2 3 (ATONs) is a novel treatment for solid malignancies. This study was performed to evaluate the feasibility and therapeutic effect of AEH with As2O3 nanoparticles in a rabbit liver cancer model. The protocol was approved by our institutional animal use committee. Methodology/Principal Findings: In total, 60 VX2 liver-tumor-bearing rabbits were randomly assigned to five groups (n = 12/group) and received AEH with ATONs (Group 1), hepatic arterial embolization with ATONs (Group 2), lipiodol (Group 3), or saline (Group 4), on day 14 after tumor implantation. Twelve r