associations between variation in chrna5-chrna3-chrnb4, body mass index and blood pressure in the northern finland birth cohort 1966chrna5-chrna3-chrnb4变化之间的联系,身体质量指数和血压在芬兰北部1966年出生队列.pdfVIP

Associations between Variation in CHRNA5-CHRNA3- CHRNB4, Body Mass Index and Blood Pressure in the Northern Finland Birth Cohort 1966 1,2 3,4 ¨ ¨ 2,5,6 ¨ ¨ ¨ 5 ¨ 1,2,7,8 Marika Kaakinen *, Francesca Ducci , Mikko J. Sillanpaa , Esa Laara , Marjo-Riitta Jarvelin 1 Institute of Health Sciences, University of Oulu, Oulu, Finland, 2 Biocenter Oulu, Oulu, Finland, 3 Psychological Medicine, Institute of Psychiatry, King’s College, London, United Kingdom, 4 Division of Mental Health, St. George’s University of London, London, United Kingdom, 5 Department of Mathematical Sciences, University of Oulu, Oulu, Finland, 6 Department of Biology, University of Oulu, Oulu, Finland, 7 Department of Life Course and Services, National Institute for Health and Welfare, Oulu, Finland, 8 Department of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, Imperial College London, London, United Kingdom Abstract Background: The CHRNA5-CHRNA3-CHRNB4 gene cluster on 15q25 has consistently been associated with smoking quantity, nicotine dependence and lung cancer. Recent research also points towards its involvement in cardiovascular homeostasis, but studies in large human samples are lacking, especially on the role of the gene cluster in blood pressure regulation. Methodology/Principal Findings: We studied the associations between 18 single nucleotide polymorphisms (SNPs) in CHRNA5-CHRNA3-CHRNB4 and systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI) in 5402 young adults from the Northern Finland Birth Cohort 1966. We observed some evidence for associations between two SNPs and SBP and between six SNPs and BMI; the evidence for associations with DBP was weaker. The association