associations of insulin and insulin-like growth factors with physical performance in old age in the boyd orr and caerphilly studies协会的胰岛素和胰岛素样生长因子和物理性能在老博伊德奥尔和卡尔菲利干酪研究.pdfVIP

Associations of Insulin and Insulin-Like Growth Factors with Physical Performance in Old Age in the Boyd Orr and Caerphilly Studies 1 1 2 1 3 4 Kate Birnie *, Yoav Ben-Shlomo , Jeff M. P. Holly , David Gunnell , Shah Ebrahim , Antony Bayer , John Gallacher4, Richard M. Martin1 1 School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, 2 School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, 3 London School of Hygiene Tropical Medicine, London, United Kingdom, 4 School of Medicine, Cardiff University, Cardiff, United Kingdom Abstract Objective: Insulin and the insulin-like growth factor (IGF) system regulate growth and are involved in determining muscle mass, strength and body composition. We hypothesised that IGF-I and IGF-II are associated with improved, and insulin with worse, physical performance in old age. Methods: Physical performance was measured using the get-up and go timed walk and flamingo balance test at 63–86 years. We examined prospective associations of insulin, IGF-I, IGF-II and IGFBP-3 with physical performance in the UK-based Caerphilly Prospective Study (CaPS; n = 739 men); and cross-sectional insulin, IGF-I, IGF-II, IGFBP-2 and IGFBP-3 in the Boyd Orr cohort (n = 182 men, 223 women). Results: In confounder-adjusted models, there was some evidence in CaPS that a standard deviation (SD) increase in IGF-I was associated with 1.5% faster get-up and go test times (95% CI: 20.2%, 3.2%; p = 0.08), but little association with poor balance, 19 years later. Coefficients in Boyd Orr were in the same direction as CaPS, but consistent with chance. Higher levels of insulin were weakly associated with worse physical performance (CaPS and Boyd Orr