behavioural and developmental interventions for autism spectrum disorder a clinical systematic review行为和发展干预对自闭症谱系障碍临床系统综述.pdfVIP

Behavioural and Developmental Interventions for Autism Spectrum Disorder: A Clinical Systematic Review 1 1 2 1 1 Maria B. Ospina , Jennifer Krebs Seida , Brenda Clark , Mohammad Karkhaneh , Lisa Hartling , Lisa 1 1 3 Tjosvold , Ben Vandermeer , Veronica Smith * 1 Alberta Research Centre for Health Evidence, University of Alberta, Edmonton, Alberta, Canada, 2 Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada, 3 Department of Educational Psychology, Faculty of Education, University of Alberta, Edmonton, Alberta, Canada Abstract Background: Much controversy exists regarding the clinical efficacy of behavioural and developmental interventions for improving the core symptoms of autism spectrum disorders (ASD). We conducted a systematic review to summarize the evidence on the effectiveness of behavioural and developmental interventions for ASD. Methods and Findings: Comprehensive searches were conducted in 22 electronic databases through May 2007. Further information was obtained through hand searching journals, searching reference lists, databases of theses and dissertations, and contacting experts in the field. Experimental and observational analytic studies were included if they were written in English and reported the efficacy of any behavioural or developmental intervention for individuals with ASD. Two independent reviewers made the final study selection, extracted data, and reached consensus on study quality. Results were summarized descriptively and, where possible, meta-analyses of the study results were conducted. One-hundred-and-one studies at predominantly high risk of bias t