benchmark for time in therapeutic range in venous thromboembolism a systematic review and meta-analysis基准时间静脉血栓治疗范围的系统回顾和荟萃分析.pdfVIP

Benchmark for Time in Therapeutic Range in Venous Thromboembolism: A Systematic Review and Meta- Analysis 1 2 ¨ 3 4 Petra M. G. Erkens *, Hugo ten Cate , Harry R. Buller , Martin H. Prins 1 Department of Family Medicine, School for Public Health and Primary Care and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands, 2 Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands, 3 Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands, 4 Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, The Netherlands Abstract Introduction: The percentage of time within the target INR range 2.0 to 3.0 (TTR) in patients treated with vitamin K antagonists varies considerably among efficacy-studies of novel anticoagulants. In order to properly asses the quality of anticoagulant control in upcoming cost-effectiveness studies and real life registries this systematic review reports a benchmark of TTR for different treatment durations in patients with venous thromboembolism and discusses ways to calculate TTR. Methods: Medline and Embase were searched for studies published between January 1990 and May 2012. Randomized controlled trials and cohort studies reporting the TTR in patients with objectively confirmed venous thromboembolism treated with vitamin K antagonists (VKA) were eligible. Duplicate reports, studies only reporting INR during initial treatment or with VKA treatment less than 3 months were excluded. Three authors assessed trials for inclusion an