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Open access, freely available online Synopses of Research Articles Assessing the Risks of Twin Pregnancies DOI: 10.1371/journal.pmed.0020195 As mothers get older and assisted transfusion syndrome (the smaller twin that the prospective risk for fetal death in conception becomes more common [donor] does not get enough blood these pregnancies might be eliminated in developed countries, the incidence while the larger twin [recipient] becomes by elective preterm delivery after 32 of multiple births—primarily of volume overloaded) and intrauterine weeks. nonidentical siblings, but also of identical growth restriction. However, the In an accompanying Perspective (DOI: ones—has dramatically increased. majority of diamniotic monochorionic 10.1371/journal.pmed.0020180), Jane Multiple pregnancies are high-risk twin pregnancies do not develop such Cleary-Goldman and Mary D’Alton agree pregnancies, with preterm delivery and complications. that, despite the limitations of the study monochorionicity (shared placenta) the Nicholas Fisk and colleagues (its retrospective nature, small numbers, major problems. Consequently, efforts are have studied records of 151 and lack of dichorionic controls), underway to optimize the management seemingly uncomplicated diamniotic it highlights a critical question for of these pregnancies. monochorionic pregnancies and found a obstetricians, namely, “when is the ideal While identical (monozygotic) twins