brain network analysis separating cost from topology using cost-integration脑网络分析分离成本使用cost-integration从拓扑.pdfVIP

Brain Network Analysis: Separating Cost from Topology Using Cost-Integration 1,2 3 4 1,2 Cedric E. Ginestet *, Thomas E. Nichols , Ed T. Bullmore , Andrew Simmons 1 Department of Neuroimaging, Institute of Psychiatry, King’s College London, London, United Kingdom, 2 National Institute of Health Research (NIHR) Biomedical Research Centre for Mental Health, Institute of Psychiatry, King’s College London, London, United Kingdom, 3 Department of Statistics, University of Warwick, Coventry, United Kingdom, 4 Brain Mapping Unit, Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom Abstract A statistically principled way of conducting brain network analysis is still lacking. Comparison of different populations of brain networks is hard because topology is inherently dependent on wiring cost, where cost is defined as the number of edges in an unweighted graph. In this paper, we evaluate the benefits and limitations associated with using cost-integrated topological metrics. Our focus is on comparing populations of weighted undirected graphs that differ in mean association weight, using global efficiency. Our key result shows that integrating over cost is equivalent to controlling for any monotonic transformation of the weight set of a weighted graph. That is, when integrating over cost, we eliminate the differences in topology that may be due to a monotonic transformation of the weight set. Our result holds for any unweighted topological measure, and for any choice of distribution over cost levels. Cost-integration is therefore helpful in disentangling differences in cost from differences in topology. By contrast, we show that the use of the weighted versio