beta-catenin signaling plays a disparate role in different phases of fracture repair implications for therapy to improve bone healingβ-连环蛋白信号在骨折修复的不同阶段发挥着不同的作用对治疗改善骨愈合.pdfVIP

PLoS MEDICINE Beta-Catenin Signaling Plays a Disparate Role in Different Phases of Fracture Repair: Implications for Therapy to Improve Bone Healing 1 1 1 1 1 1 Yan Chen , Heather C. Whetstone , Alvin C. Lin , Puviindran Nadesan , Qingxia Wei , Raymond Poon , Benjamin A. Alman1,2* 1 Program in Developmental and Stem Cell Biology, the Hospital for Sick Children, University of Toronto, Toronto, Canada, 2 Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada Funding: This work was supported A B S T R A C T by grants from the Canadian Institute of Health Research. The funders had no role in study design, data collection and analysis, decision Background to publish, or preparation of the manuscript. Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve fracture repair would substantially Competing Interests: The authors improve patient outcome. The signaling pathways regulating bone healing are beginning to be have declared that no competing interests exist. unraveled, and they provide clues into pharmacologic management. The b-catenin signaling pathway, which activates T cell factor (TCF)-dependent transcription, has emerged as a key Academic Editor: William Horton, Shriner’s Hospital Portland, United regulator in embryonic skeletogenesis, positively regulating osteoblasts. However, its role in States of America