beta adrenergic overstimulation impaired vascular contractility via actin-cytoskeleton disorganization in rabbit cerebral arteryβ肾上腺素能通过actin-cytoskeleton无序过度刺激受损的血管收缩性在兔脑动脉.pdfVIP

Beta Adrenergic Overstimulation Impaired Vascular Contractility via Actin-Cytoskeleton Disorganization in Rabbit Cerebral Artery 1 2 3 4 5 1 Hyoung Kyu Kim , Won Sun Park , Mohamad Warda , So Youn Park , Eun A. Ko , Min Hee Kim , Seung 1 1 6 7 7 1 Hun Jeong , Hye-Jin Heo , Tae-Hoon Choi , Young-Won Hwang , Sun-Il Lee , Kyung Soo Ko , Byoung 1 1. 1 . Doo Rhee , Nari Kim , Jin Han * 1 National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea, 2 Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Korea, 3 Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt, 4 Department of Pharmacology, College of Medicine and Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Busan, Korea, 5 Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, 6 Department of Physical Education, Andong Science College, Andong, Korea, 7 Department of Neurosurgery, College of Medicine, Inje University, Busan Paik Hospital, Busan, Korea Abstract Background and Purpose: Beta adrenergic overstimulation may increase the vascular damage and stroke. However, the underlying mechanisms of beta adrenergic overstimulation in cerebrovascular dysfunctions are not well known. We investigated the possible cerebrov