beta-adrenergic receptor 1 selective antagonism inhibits norepinephrine-mediated tnf-alpha downregulation in experimental liver cirrhosis在差别该项受体1选择性对抗抑制norepinephrine-mediated tnf对这些实验性肝硬化.pdfVIP

Beta-Adrenergic Receptor 1 Selective Antagonism Inhibits Norepinephrine-Mediated TNF-Alpha Downregulation in Experimental Liver Cirrhosis 1,2 ´ 1,3 ´ 4 ´ ´ 1,3 Pedro Zapater , Isabel Gomez-Hurtado , Gloria Peiro , Jose Manuel Gonzalez-Navajas , ´ 1,3 ´ 1,3 1,3 ´ 1,3 ´ ´ 1,3 Irma Garcıa , Paula Gimenez , Alba Moratalla , Jose Such , Ruben Frances * 1 The Biomedical Research Centre Network in the Area of Hepatic and Digestive Disorders (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, 2 Servicio de ´ ´ ´ ´ Farmacologıa Clınica, Hospital General Universitario, Alicante, Spain, 3 Unidad Hepatica, Hospital General Universitario, Alicante, Spain, 4 Unidad de Investigacion, Hospital General Universitario, Alicante, Spain Abstract Background: Bacterial translocation is a frequent event in cirrhosis leading to an increased inflammatory response. Splanchnic adrenergic system hyperactivation has been related with increased bacterial translocation. We aim at evaluating the interacting mechanism between hepatic norepinephrine and inflammation during liver damage in the presence of bacterial-DNA. Animals and Methods: Forty-six mice were included in a 16-week protocol of CCl -induced cirrhosis. Laparotomies were 4 performed at we