calories do not explain extension of life span by dietary restriction in drosophila热量不能解释在果蝇扩展寿命的饮食限制.pdfVIP

Open access, freely available online PLoS BIOLOGY Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila * William Mair, Matthew D. W. Piper, Linda Partridge Centre for Research on Ageing, University College London, Department of Biology, London, United Kingdom Dietary restriction (DR) extends life span in diverse organisms, including mammals, and common mechanisms may be at work. DR is often known as calorie restriction, because it has been suggested that reduction of calories, rather than of particular nutrients in the diet, mediates extension of life span in rodents. We here demonstrate that extension of life span by DR in Drosophila is not attributable to the reduction in calorie intake. Reduction of either dietary yeast or sugar can reduce mortality and extend life span, but by an amount that is unrelated to the calorie content of the food, and with yeast having a much greater effect per calorie than does sugar. Calorie intake is therefore not the key factor in the reduction of mortality rate by DR in this species. Citation: Mair W, Piper MDW, Partridge L (2005) Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol 3(7): e223. Introduction medium [9] in which the yeast is the only source of protein and lipid. As food concentration declines from maximum, life Dietary restriction (DR), the extension of life span by span first increases in response to DR, becoming greatest at reduction of nutrient intake without malnutrition, is often an intermediate food concentration, before declining due to used as a benchmark