cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains心血管反应该项封锁在23近交品系小鼠或激活.pdfVIP

Cardiovascular Response to Beta-Adrenergic Blockade or Activation in 23 Inbred Mouse Strains 1,2. 2,3. ¨ 1 1 ´ 2,3 Corinne Berthonneche , Bastian Peter , Fanny Schupfer , Pamela Hayoz , Zoltan Kutalik , Hugues 4,5 6 1,2 2,3 1 Abriel , Thierry Pedrazzini , Jacques S. Beckmann , Sven Bergmann , Fabienne Maurer * 1 Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland, 2 Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, 3 Swiss Institute of Bioinformatics, Lausanne, Switzerland, 4 Department of Pharmacology and Service of Cardiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland, 5 Department of Clinical Research, University of Bern, Bern, Switzerland, 6 Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Abstract We report the characterisation of 27 cardiovascular-related traits in 23 inbred mouse strains. Mice were phenotyped either in response to chronic administration of a single dose of the b-adrenergic receptor blocker atenolol or under a low and a high dose of the b-agonist isoproterenol and compared to baseline condition. The robustness of our data is supported by high trait heritabilities (typically H2 .0.7) and significant correlations of trait values measured in baseline condition with independent multistrain datasets of the Mouse Phenome Database. We then focused on the dr