cell-to-cell interactions and signals involved in the reconstitution of peripheral cd8+ tcm and tem cell pools细胞间的相互作用和信号参与调整外围cd8 +中医和tem细胞池.pdfVIP

Cell-to-Cell Interactions and Signals Involved in the Reconstitution of Peripheral CD8+ TCM and TEM Cell Pools 1 ´ 2 3¤a 4 3 Bruno Zaragoza , Cesar Evaristo , Adrien Kissenpfennig , Valentina Libri , Bernard Malissen , 2 ´ 1 1 ¤b Benedita Rocha , Antonio A. Freitas *, Afonso R. M. Almeida * ´ 1 Lymphocyte Population Biology Unit, CNRS, URA 1961, Institut Pasteur, Paris, France, 2 INSERM, U591, Institut Federatif de Recherche 94, Universite Paris-Descartes, ´ ´ ´ Paris, France, 3 INSERM, U631, CNRS, UMR6102, Centre d’Immunologie de Marseille-Luminy, Universite de la Mediterrannee, Marseille, France, 4 U. Signalisation des cytokines, CNRS, Institut Pasteur, Paris, France Abstract We here describe novel aspects of CD8+ and CD4+ T cell subset interactions that may be clinically relevant and provide new tools for regulating the reconstitution of the peripheral CD8+ T cell pools in immune-deficient states. We show that the ¨ + reconstitution capacity of transferred isolated naıve CD8 T cells and their differentiation of effector functions is limited, but both dramatically increase upon the co-transfer of CD4+ T cells. This helper effect is complex and determined by multiple facto