原创力文档calcium prevents tumorigenesis in a mouse model of colorectal cancer钙可以防止肿瘤发生在结肠直肠癌的小鼠模型.pdfVIP
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calcium prevents tumorigenesis in a mouse model of colorectal cancer钙可以防止肿瘤发生在结肠直肠癌的小鼠模型
Calcium Prevents Tumorigenesis in a Mouse Model of
Colorectal Cancer
1. 1. 1 1 1 2 1
Ji-Lin Wang , Yan-Wei Lin , Hui-Min Chen , Xuan Kong , Hua Xiong , Nan Shen , Jie Hong , Jing-Yuan
Fang1*
1 Division of Gastroenterology, Shanghai Jiao-Tong University School of Medicine, Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China, 2 Division of
Rheumatology, Shanghai Jiao-Tong University School of Medicine, Renji Hospital, Shanghai, China
Abstract
Background and Aim: Calcium has been proposed as a mediator of the chemoprevention of colorectal cancer (CRC), but
the comprehensive mechanism underlying this preventive effect is not yet clear. Hence, we conducted this study to
evaluate the possible roles and mechanisms of calcium-mediated prevention of CRC induced by 1,2-dimethylhydrazine
(DMH) in mice.
Methods: For gene expression analysis, 6 non-tumor colorectal tissues of mice from the DMH + Calcium group and 3
samples each from the DMH and control groups were hybridized on a 4 644 K Agilent whole genome oligo microarray, and
selected genes were validated by real-time polymerase chain reaction (PCR). Functional analysis of the microarray data was
performed using KEGG and Gene Ontology (GO) analyses. Hub genes were identified using Pathway Studio software.
Results: The tumor incidence rates in the DMH and DMH + Calcium groups were 90% and 40%, respectively. Microarray
gene expression analysis showed that S100a9, Defa20, Mmp10, Mmp7, Ptgs2, and Ang2 were among the most
downregulated genes, whereas Per3, Tef, Rnf152, and Prdx6 were significantly upregulated in the DMH + Calcium group
compared with the DMH group. Functional a
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