calorie restriction increases muscle mitochondrial biogenesis in healthy humans在健康人体内卡路里限制增加肌肉线粒体生物起源.pdfVIP

PLoS MEDICINE Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans * Anthony E. Civitarese , Stacy Carling, Leonie K. Heilbronn, Mathew H. Hulver, Barbara Ukropcova, Walter A. Deutsch, Steven R. Smith, Eric Ravussin for the CALERIE Pennington Team Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America Funding: This study was supported A B S T R A C T by RO1 AG20478 (ER), and partly by a CNRU Center Grant #1P30 DK072476 entitled Nutritional Programming: Environmental and Background Molecular Interactions. The funders had no role in study design, data Caloric restriction without malnutrition extends life span in a range of organisms including collection and analysis, decision to insects and mammals and lowers free radical production by the mitochondria. However, the publish, or preparation of the mechanism responsible for this adaptation are poorly understood. manuscript. Competing Interests: The authors have declared that no competing Methods and Findings interests exist. The current study was undertaken to examine muscle mitochondrial bioenergetics in Academic Editor: Nir Barzilai, Albert response to caloric restriction alone or in combination with exercise in 36 young (36.8 6 1.0 y), Einstein College of Medicine, United overweight (body mass index, 27.8 6 0.7 kg/m2) individuals randomized into one of three States of America groups for a 6-mo intervention: Control, 100% of energy requirements; CR, 25% caloric Citation: Civitarese AE, Carling S,