central projection of pain arising from delayed onset muscle soreness (doms) in human subjects中心投影的疼痛引起的延迟性肌肉酸痛(doms)在人类主题.pdfVIP

Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects Katharina Zimmermann*, Caroline Leidl, Miriam Kaschka, Richard W. Carr¤a, Pavel Terekhin¤b, Hermann O. Handwerker, Clemens Forster Department of Physiology and Pathophysiology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany Abstract Delayed onset muscle soreness (DOMS) is a subacute pain state arising 24–48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI) was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle of healthy volunteers evoked by either voluntary contraction or physical stimulation. The painful movement or physical stimulation of the DOMS-affected thigh disclosed widespread activation in the primary somatosensory and motor (S1, M1) cortices, stretching far beyond the corresponding areas somatotopically related to contraction or physical stimulation of the thigh; activation also included a large area within the cingulate cortex encompassing posteroanterior regions and the cingulate motor area. Pain-related activations were also found in premotor (M2) areas, bilateral in the insular cortex and the thalamic nuclei. In contrast, movement of a DOMS- affected limb led also to activation in the ipsilateral anterior cerebellum, while DOMS-related pain evoked by physical stimulation devoid of limb movement did not. Citation: Zimmermann K, Leidl C, Kaschka M, Carr RW, Terekhin P, et al. (2012) Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects. PLoS ONE 7(10): e47230. doi:10.1371/journal.pone.0047230 Editor: Essa Yacoub, University of Minnesota, United States of America Received June 22, 2012; Accepted September 10, 2012; Published October 8, 2012