chronic oral infection with porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile慢性口腔感染porphyromonas gingivalis加速动脉粥样化形成通过将血脂.pdfVIP

Chronic Oral Infection with Porphyromonas gingivalis Accelerates Atheroma Formation by Shifting the Lipid Profile 1,2. 1,2. 1 1,2 1,2 Tomoki Maekawa , Naoki Takahashi , Koichi Tabeta , Yukari Aoki , Hirotaka Miyashita , Sayuri Miyauchi1,2, Haruna Miyazawa1,2, Takako Nakajima1,3, Kazuhisa Yamazaki1,2* 1 Center for Transdisciplinary Research, Niigata University, Niigata, Japan, 2 Laboratory of Periodontology and Immunology, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 3 General Dentistry and Clinical Education Unit, Niigata University Medical and Dental Hospital, Niigata, Japan Abstract Background: Recent studies have suggested that periodontal disease increases the risk of atherothrombotic disease. Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol deposition in the arteries. Although several studies have suggested that certain periodontopathic bacteria accelerate atherogenesis in apolipoprotein E-deficient mice, the mechanistic link between cholesterol accumulation and periodontal infection-induced inflammation is largely unknown. Methodology/Principal Findings: We orally infected C57BL/6 and C57BL/6.KOR-Apoeshl (B6.Apoeshl) mice with Porphyromonas gingivalis, which is a representative periodontopathic bacterium, and evaluated atherogenesis, gene expression in the aorta and liver and systemic inflammatory and lipid profiles in the blood. Furthermore, the effect of lipopolysaccharide (LPS) from P. gin