changes in body weight and psychotropic drugs a systematic synthesis of the literature体重的变化和精神药品系统合成的文献.pdfVIP

Review Changes in Body Weight and Psychotropic Drugs: A Systematic Synthesis of the Literature 1,3 1 2 3 3 1 Robert Dent *, Angelique Blackmore , Joan Peterson , Rami Habib , Gary Peter Kay , Alan Gervais , Valerie Taylor4, George Wells5 1 Weight Management Clinic, Ottawa Hospital, Ontario, Canada, 2 Ottawa Health Research Institute, Ottawa, Ontario, Canada, 3 Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada, 4 University of Toronto, Toronto, Ontario, Canada, 5 Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada [9–14], for antipsychotic medications [15–22] and for lithium Abstract: Introduction: Psychotropic medication use is [23,24] and has been cited by an expert consensus panel on associated with weight gain. While there are studies and adherence problems in serious and persistent mental illness reviews comparing weight gain for psychotropics within [25,26]. Non-adherence to prescribed medications places patients some classes, clinicians frequently use drugs from at a greatly increased risk of illness exacerbation and re- different classes to treat psychiatric disorders. hospitalization. These costs are high [27], and were estimated to Objective: To undertake a systematic review of all classes range from $ 1392 million to $ 1826 million in 2005 in the US for of psychotropics