cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts癌细胞的表达autotaxin控制骨转移形成鼠标通过lysophosphatidic acid-dependent激活破骨细胞.pdfVIP

Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts 1,2,3 4 5 6 1,2,3 Marion David , Estelle Wannecq , Franc¸oise Descotes , Silvia Jansen , Blandine Deux , Johnny 1,2,3 1,2,3 ` 4 7,8 6 Ribeiro , Claire-Marie Serre , Sandra Gres , Nathalie Bendriss-Vermare , Mathieu Bollen , Simone 5 9 ´ 4 ´ 1,2,3 1,2,3 Saez , Junken Aoki , Jean-Sebastien Saulnier-Blache , Philippe Clezardin , Olivier Peyruchaud * ´ ´ ´ 1 INSERM, U664, Lyon, France, 2 Universite Claude Bernard Lyon 1, Villeurbanne, France, 3 Faculte de Medecine Laennec, Lyon, France, 4 INSERM, U858, Toulouse, France, ´ 5 Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre Benite, France, 6 Laboratory of Biosignaling and Therapeutics, Department of Molecular Cell Biology, ´ University of Leuven, Leuven, Belgium, 7 INSERM, U590, Lyon, France, 8 Centre Leon Berard, Lyon, France, 9 Tohoku University, Sendai, Japan Abstract Background: Bone metastases are highly frequent complications of breast cancers. Current bone metastasis