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Bone Surface Mapping Method 1 2 3 1 1 Yifang Fan *, Yubo Fan *, Zhiyu Li , Changsheng Lv , Bo Zhang 1 Center for Scientific Research, Guangzhou Institute of Physical Education, Guangzhou, People’s Republic of China, 2 Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, People’s Republic of China, 3 College of Foreign Studies, Jinan University, Guangzhou, People’s Republic of China Abstract Bone shape is an important factor to determine the bone’s structural function. For the asymmetrically shaped and anisotropically distributed bone in vivo, a surface mapping method is proposed on the bases of its geometric transformation invariance and its uniqueness of the principal axes of inertia. Using spiral CT scanning, we can make precise measurements to bone in vivo. The coordinate transformations lead to the principal axes of inertia, with which the prime meridian and the contour can be set. Methods such as tomographic reconstruction and boundary development are employed so that the surface of bone in vivo can be mapped. Experimental results show that the surface mapping method can reflect the shape features and help study the surface changes of bone in vivo. This method can be applied to research into the surface characteristics and changes of organ, tissue or cell whenever its digitalized surface is obtained. Citation: Fan Y, Fan Y, Li Z, Lv C, Zhang B (2012) Bone Surface Mapping Method. PLoS ONE 7(3): e32926. doi:10.1371/journal.pone.0032926 Editor: Yong Fan, Institution of Automation, CAS, China Received August 15, 2011; Accepted February 5, 2012; Published March 8, 2012 Cop