baseline predictors of sputum culture conversion in pulmonary tuberculosis importance of cavities, smoking, time to detection and w-beijing genotype基线预测肺结核痰文化转换的蛀牙的重要性,吸烟,时间检测和w-beijing基因型.pdfVIP

Baseline Predictors of Sputum Culture Conversion in Pulmonary Tuberculosis: Importance of Cavities, Smoking, Time to Detection and W-Beijing Genotype 1 2,3 2 2 4 Marianne E. Visser *, Michael C. Stead , Gerhard Walzl , Rob Warren , Michael Schomaker , 5 6 7 Harleen M. S. Grewal , Elizabeth C. Swart , Gary Maartens 1 School of Public Health, University of the Western Cape, Cape Town, South Africa, 2 MRC Centre for Molecular and Cellular Biology, University of Stellenbosch, Cape Town, South Africa, 3 Division of Medical Microbiology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa, 4 School of Public Health and Family Medicine, Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa, 5 Section of Microbiology and Immunology, The Gade Institute, University of Bergen, Haukeland University Hospital, Bergen, Norway, 6 Division of Dietetics, University of the Western Cape, Cape Town, South Africa, 7 Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Abstract Background: Time to detection (TTD) on automated liquid mycobacterial cultures is an emerging biomarker of tuberculosis outcomes. The M. tuberculosis W-Beijing genotype is spreading globally, indicating a selective advantage. There is a paucity of data on the association between baseline TTD and W-Beijing genotype and tuberculosis outcomes. Aim: To assess baseline predictors of failure of sputum culture conversion, within the first 2 months of antitubercular therapy, in participants with pulmonary tuberculosis. Desi