association of transcription factor gene lmx1b with autism自闭症协会的转录因子基因lmx1b.pdfVIP

Association of Transcription Factor Gene LMX1B with Autism 1. 1 . 2. 3. 4 Ismail Thanseem , Kazuhiko Nakamura * , Ayyappan Anitha , Shiro Suda , Kazuo Yamada , Yoshimi 4 4 2,5 1 2 2 Iwayama , Tomoko Toyota , Masatsugu Tsujii , Yasuhide Iwata , Katsuaki Suzuki , Hideo Matsuzaki , 2 6,7 4 1,2 Keiko Iwata , Toshiro Sugiyama , Takeo Yoshikawa , Norio Mori 1 Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan, 2 Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan, 3 Department of Psychiatry, Jichi Medical University, Shimotsuke, Japan, 4 Laboratory of Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan, 5 Faculty of Sociology, Chukyo University, Toyota, Aichi, Japan, 6 Aichi Children’s Health and Medical Center, Obu, Aichi, Japan, 7 Department of Child and Adolescent Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan Abstract Multiple lines of evidence suggest a serotoninergic dysfunction in autism. The role of LMX1B in the development and maintenance of serotoninergic neurons is well known. In order to examine the role, if any, of LMX1B with autism pathophysiology, a trio-based SNP association study using 252 family samples from the AGRE was performed. Using pair- wise tagging method, 24 SNPs were selected from the HapMap data, based on their location and min