associations between purine metabolites and clinical symptoms in schizophrenia嘌呤代谢物之间的关联,在精神分裂症的临床症状.pdfVIP

Associations between Purine Metabolites and Clinical Symptoms in Schizophrenia Jeffrey K. Yao1,2,3*, Ruth Condray1,2, George G. Dougherty Jr.1,2, Matcheri S. Keshavan2,4, 2 5 6 6 1,2 Debra M. Montrose , Wayne R. Matson , Joseph McEvoy , Rima Kaddurah-Daouk , Ravinder D. Reddy 1Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States of America, 2 Department of Psychiatry, Western Psychiatric Institute Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America, 3 Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, United States of America, 4 Beth Israel Deaconess Medical Center and Harvard University, Boston, Massachusetts, United States of America, 5 Bedford Veterans Affairs Medical Center, Bedford, Massachusetts, United States of America, 6 Duke University Medical Center, Durham, North Carolina, United States of America Abstract Background: The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology of schizophrenia. Methodology/Principal Findings: Breakdown products in purine pathway were measured using high-pressure liquid ¨ chromatography coupled with a coulometric multi-electrode array system for 25 first-episode neuroleptic-naıve patients with schizophrenia at baseline and at 4-weeks following i