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Synopses of Research Articles A Smart Mutation Scheme Produces Hundreds of Functional Proteins Richard Robinson | DOI: 10.1371/journal.pbio.0040136 A protein’s structure dictates its proteins. Detailed analysis revealed the function, and one of the most direct contribution to catalytic activity of a and powerful ways to explore a previously unappreciated amino acid protein’s function is by modifying near the enzyme’s active site. Some its structure. Such an exploration of the mutants were more resistant to is carried out naturally every time a heat degradation than the originals, protein’s gene is mutated, and the indicating the potential for creating same process can be mimicked in the novel and possibly useful new variants lab. Unfortunately, approaches that using this method. introduce random mutations frequently The mutation method used here disrupt the interactions that keep a increased the yield of properly folded protein properly folded, rendering cytochromes by 10,000-fold over the mutant entirely functionless DOI: 10.1371/journal.pbio.0040136.g001 entirely random mutation techniques,