associations between total cerebral blood flow and age related changes of the brain总脑血流量之间的关联和年龄有关的大脑变化.pdfVIP

Associations between Total Cerebral Blood Flow and Age Related Changes of the Brain 1 1 2 2 Adriaan C. G. M. van Es *, Jeroen van der Grond , V. Hester ten Dam , Anton J. M. de Craen , Gerard J. 2 2 3 1 Blauw , Rudi G. J. Westendorp , Faiza Admiraal-Behloul , Mark A. van Buchem , for the PROSPER Study Group 1 Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands, 2 Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands, 3 Section of Image Processing (LKEB), Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands Abstract Background and Purpose: Although total cerebral blood flow (tCBF) is known to be related to age, less is known regarding the associations between tCBF and the morphologic changes of the brain accompanying cerebral aging. The purpose of this study was to investigate whether total cerebral blood flow (tCBF) is related to white matter hyperintensity (WMH) volume and/or cerebral atrophy. Furthermore, we investigate whether tCBF should be expressed in mL/min, as was done in all previous MR studies, or in mL/100 mL/min, which yielded good results in precious SPECT, PET and perfusion MRI studies investigating regional cerebral blood flow. Materials and Methods: Patients were included from the nested MRI sub-study of the PROSPER study. Dual fast spin echo and FLAIR images were obtained in all patients. In addition, single slice phase contrast MR angiography was used for flow measurements in the internal carotids and vertebral arteries. tCBF was expressed in both mL/min and mL/100 mL