associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy chinese糊精协会与炎症标记物和代谢综合征在看似健康的中国人.pdfVIP

Associations of Amylin with Inflammatory Markers and Metabolic Syndrome in Apparently Healthy Chinese 1. 1. 1 1 1 1 2 Xinwei Hou , Liang Sun , Zongmeng Li , Haiwei Mou , Zhijie Yu , Huaixing Li , Peizhen Jiang , Danxia 1 1 1 1 1 Yu , Hongyu Wu , Xingwang Ye , Xu Lin *, Yingying Le * 1 Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China, 2 Shanghai Municipal Center for Disease Control Prevention, Shanghai, China Abstract Background: Cellular and animal studies implicate multiple roles of amylin in regulating insulin action, glucose and lipid metabolisms. However, the role of amylin in obesity related metabolic disorders has not been thoroughly investigated in humans. Therefore, we aimed to evaluate the distribution of circulating amylin and its association with metabolic syndrome (MetS) and explore if this association is influenced by obesity, inflammatory markers or insulin resistance in apparently healthy Chinese. Methods: A population-based sample of 1,011 Chinese men and women aged 35–54 years was employed to measure plasma amylin, inflammatory markers (C-reactive protein [CRP] and interleukin-6 [IL-6]), insulin, glucose and lipid profiles. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: Plasma amylin concentrations were higher in overweight/obese participants than normal-weight counterparts (P,0.001) without sex difference. Circu