batf3-dependent cd11blow？ peripheral dendritic cells are gm-csf-independent and are not required for th cell priming after subcutaneous immunizationbatf3-dependent cd11blow 外围树突细胞gm-csf-independent和不需要th细胞皮下接种后启动.pdfVIP

Batf3-Dependent CD11blow/2 Peripheral Dendritic Cells Are GM-CSF-Independent and Are Not Required for Th Cell Priming after Subcutaneous Immunization 1 1 1 1,2¤ 1 3 Brian T. Edelson , Tara R. Bradstreet , Wumesh KC , Kai Hildner , Jeremy W. Herzog , Julia Sim , 3 1 1 1,2 John H. Russell , Theresa L. Murphy , Emil R. Unanue , Kenneth M. Murphy * 1 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2 Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America, 3 Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America Abstract Dendritic cells (DCs) subsets differ in precursor cell of origin, functional properties, requirements for growth factors, and dependence on transcription factors. Lymphoid-tissue resident CD8a+ conventional DCs (cDCs) and CD11blow/2CD103+ non-lymphoid DCs are developmentally related, each being dependent on FMS-like tyrosine kinase 3 ligand (Flt3L), and requiring the transcription factors Batf3, Irf8, and Id2 for development. It was recently suggested that granulocyte/ macrophage colony stimulating factor (GM-CSF) was required for the development of dermal CD11blow/2 + + Langerin CD1