balancing selection maintains a form of erap2 that undergoes nonsense-mediated decay and affects antigen presentation平衡选择保持一种erap2经历nonsense-mediated腐蚀和影响抗原表达.pdfVIP

Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation ´ 1.¤a 1.¤b 1 2 Aida M. Andres *, Megan Y. Dennis , Warren W. Kretzschmar , Jennifer L. Cannons , Shih-Queen 1 1 1,3 2 Lee-Lin , Belen Hurle , NISC Comparative Sequencing Program , Pamela L. Schwartzberg , Scott H. 4{ 4¤c 5 6 1,3 Williamson , Carlos D. Bustamante , Rasmus Nielsen , Andrew G. Clark , Eric D. Green 1 Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 2 Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 3 NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 4 Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, 5 Department of Integrative Biology, University of California, Berkeley, Berkeley, California, United States of America, 6 Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America Abstract A remarkable characteristic of the human major histocompatibility complex (MHC) is its extreme genetic diversity, which is maintained by balancing selection. In fact, the MHC complex remains one of