cancer reduces transcriptome specialization癌症减少转录组专业化.pdfVIP

Cancer Reduces Transcriptome Specialization ´ 1 ´ 2 1 Octavio Martınez *, M. Humberto Reyes-Valdes , Luis Herrera-Estrella ´ ´ ´ 1 Laboratorio Nacional de Genomica para la Biodiversidad, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Irapuato, Guanajuato, ´ ´ ´ Mexico, 2 Department of Plant Breeding, Universidad Autonoma Agraria Antonio Narro, Saltillo, Coahuila, Mexico Abstract A central goal of cancer biology is to understand how cells from this family of genetic diseases undergo specific morphological and physiological changes and regress to a de-regulated state of the cell cycle. The fact that tumors are unable to perform most of the specific functions of the original tissue led us to hypothesize that the degree of specialization of the transcriptome of cancerous tissues must be less than their normal counterparts. With the aid of information theory tools, we analyzed four datasets derived from transcriptomes of normal and tumor tissues to quantitatively test the hypothesis that cancer reduces transcriptome specialization. Here, we show that the transcriptional specialization of a tumor is significantly less than the corresponding normal tissue and comparable with the specialization of dedifferentiated embryonic stem cells. Furthermore, we demonstrate that the d