bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock骨髓提取间充质干细胞抑制炎症和保护肺出血性休克后血管内皮的完整性.pdfVIP

Bone Marrow Derived Mesenchymal Stem Cells Inhibit Inflammation and Preserve Vascular Endothelial Integrity in the Lungs after Hemorrhagic Shock 1 1 1 1 1 Shibani Pati *, Michael H. Gerber , Tyler D. Menge , Kathryn A. Wataha , Yuhai Zhao , John Adam 1 3 1 1 1 1 Baumgartner , Jing Zhao , Phillip A. Letourneau , Maria P. Huby , Lisa A. Baer , John R. Salsbury , 1 1 3 2 3 Rosemary A. Kozar , Charles E. Wade , Peter A. Walker , Pramod K. Dash , Charles S. Cox Jr. , Marie- Francoise Doursout4, John B. Holcomb1 1 Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, 2 Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, 3 Department of Pediatric Surgery, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, 4 Department of Anesthesiology, University of Texas Health Science Center at Houston, Houston, Texas, United States of America Abstract Hemorrhagic shock (HS) and trauma is currently the leading cause of death in young adults worldwide. Morbidity and mortality after HS and trauma is often the result of multi-organ failure such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), conditions with few therapeutic options. Bone marrow derived mesenchymal stem cells (MSCs) are a multipotent stem cell