changes in community structure of resting state functional connectivity in unipolar depression群落结构变化的静息状态的功能连通性单极抑郁.pdfVIP

Changes in Community Structure of Resting State Functional Connectivity in Unipolar Depression Anton Lord1,2*, Dorothea Horn3,4, Michael Breakspear1,5,6,7, Martin Walter3,4,8 1 Division of Mental Health Research, Queensland Institute of Medical Research, Brisbane, Queensland, Australia, 2 University of Queensland, St Lucia, Queensland, Australia, 3 Clinical Affective Neuroimaging Laboratory, Leibnitz Institute for Neurobiology, Magdeburg, Germany, 4 Departments of Psychiatry and Neurology, Otto v. Guericke University, Magdeburg, Germany, 5 School of Psychiatry, University of New South Wales, New South Wales, Sydney, Australia, 6 The Black Dog Institute, Sydney, New South Wales, Australia, 7 The Royal Brisbane and Womans Hospital, Brisbane, Queensland, Australia, 8 Center for Behavioral and Brain Sciences, Magdeburg, Germany Abstract Major depression is a prevalent disorder that imposes a significant burden on society, yet objective laboratory-style tests to assist in diagnosis are lacking. We employed network-based analyses of ‘‘resting state’’ functional neuroimaging data to ascertain group differences in the endogenous cortical activity between healthy and depressed subjects. We additionally sought to use machine learning techniques to explore the ability of these network-based measures of resting state activity to provide diagnostic information for depression. Resting state fMRI data were acquired from twenty two depressed outpatients and twenty two healthy subjects matched for age and gender. These data were anatomically parcellated and functional connectivity matrices were then derived using the linear correlations between the BOLD signal fluctuations of all pairs of cortical and subcortical regions. We characterised the hierarchical organization of these matrices using network- based matrics, with an emphasis on their mid-scale ‘‘