原创力文档colocalized structural and functional changes in the cortex of patients with trigeminal neuropathic pain与结构和功能变化的三叉神经痛患者的皮层.pdfVIP
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colocalized structural and functional changes in the cortex of patients with trigeminal neuropathic pain与结构和功能变化的三叉神经痛患者的皮层
Colocalized Structural and Functional Changes in the
Cortex of Patients with Trigeminal Neuropathic Pain
1.¤ 1,2. 1 3 1
Alexandre F. DaSilva *, Lino Becerra , Gautam Pendse , Boris Chizh , Shannon Tully , David
Borsook1,2
1 P.A.I.N. Group, Brain Imaging Center, Mclean Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Massachusetts General Hospital,
Harvard Medical School, Boston, Massachusetts, United States of America, 3 GSK Addenbrooks Hospital, Cambridge, United Kingdom
Abstract
Background: Recent data suggests that in chronic pain there are changes in gray matter consistent with decreased brain
volume, indicating that the disease process may produce morphological changes in the brains of those affected. However,
no study has evaluated cortical thickness in relation to specific functional changes in evoked pain. In this study we sought to
investigate structural (gray matter thickness) and functional (blood oxygenation dependent level – BOLD) changes in
cortical regions of precisely matched patients with chronic trigeminal neuropathic pain (TNP) affecting the right maxillary
(V2) division of the trigeminal nerve. The model has a number of advantages including the evaluation of specific changes
that can be mapped to known somatotopic anatomy.
Methodology/Principal Findings: Cortical regions were chosen based on sensory (Somatosensory cortex (SI and SII), motor
(MI) and posterior insula), or emotional (DLPFC, Frontal, Anterior Insula, Cingulate) processing of pain. Both structural and
functional (to brush-induced allodynia) scans were obtained and averaged from two different imaging sessions separated
by 2–6 months in all patients. Age and gender-matched hea
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