原创力文档color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis亚颜色能够解决optofluidic显微镜及其应用血液细胞成像诊断疟疾.pdfVIP
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color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis亚颜色能够解决optofluidic显微镜及其应用血液细胞成像诊断疟疾
Color Capable Sub-Pixel Resolving Optofluidic
Microscope and Its Application to Blood Cell Imaging for
Malaria Diagnosis
1 2 1 1 2 1,3
Seung Ah Lee *, Ricardo Leitao , Guoan Zheng , Samuel Yang , Ana Rodriguez , Changhuei Yang
1 Department of Electrical Engineering, California Institute of Technology, Pasadena, California, United States of America, 2 Department of Microbiology, Division of
Medical Parasitology, New York University School of Medicine, New York, New York, United States of America, 3 Department of Bioengineering, California Institute of
Technology, Pasadena, California, United States of America
Abstract
Miniaturization of imaging systems can significantly benefit clinical diagnosis in challenging environments, where access to
physicians and good equipment can be limited. Sub-pixel resolving optofluidic microscope (SROFM) offers high-resolution
imaging in the form of an on-chip device, with the combination of microfluidics and inexpensive CMOS image sensors. In
this work, we report on the implementation of color SROFM prototypes with a demonstrated optical resolution of 0.66 mm
at their highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with
Plasmodium falciparum, a particularly harmful type of malaria parasites and one of the major causes of death in the
developing world.
Citation: Lee SA, Leitao R, Zheng G, Yang S, Rodriguez A, et al. (2011) Color Capable Sub-Pixel Resolving Optofluidic Microscope and Its Application to Blood Cell
Imaging for Malaria Diagnosis. PLoS ONE 6(10): e26127. doi:10.1371/journal.pone.0026127
Editor: Arum Han, Tex
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